Friday, October 23

Missing Link Between Fructose and Insulin Resistance

Missing link between fructose, insulin resistance found

3. March 2009 22:11

A new study in mice sheds light on the insulin resistance that can come from diets loaded with high-fructose corn syrup, a sweetener found in most sodas and many other processed foods.

The report in the March issue of Cell Metabolism, a Cell Press publication, also suggests a way to prevent those ill effects.

The researchers showed that mice on a high-fructose diet were protected from insulin resistance when a gene known as transcriptional coactivator PPARg coactivator-1b (PGC-1b) was "knocked down" in the animals' liver and fat tissue. PGC-1b coactivates a number of transcription factors that control the activity of other genes, including one responsible for building fat in the liver.

"There has been a remarkable increase in consumption of high-fructose corn syrup," said Gerald Shulman of Yale University School of Medicine. "Fructose is...

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